Manganese role in health support in bone production due to altered formation of the protein matrix that keeps minerals like calcium in place. Manganese is a required co-factor for an enzyme called prolidase, which is in turn necessary to make collagen as a structural component of skin.

Manganese is needed to help multiple enzymes in a process called gluconeogenesis. This is the process by which we build non-carbohydrate food products—for example, digested fats—into sugars to burn as fuel.Also manganese is a potent antioxidant associated with protection against free radical damage. Diets low in manganese have been linked to conditions marked by increased oxidative stress, including skin problems and asthma.