Niacinamide B-3
Niacinamide B-3
Source Naturals Niacinamide, also known as vitamin B-3, functions in over 50 metabolic reactions, most of which are enzymatic.
Niacinamide bioactive forms - NAD+, NADH, NADP, and NADPH - play important roles as catalysts in the energy production process in the cells, the breakdown of proteins and fatty acids, the synthesis of fatty acids, and the formation of steroid hormones and red blood cells.
FAQ's for Niacin
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How come my skin goes red and blotchy?
This is called Niacin Flush. Niacin flush is a common side effect of taking high doses of niacin (vitamin B3), especially in its immediate-release form. -
What is a Niacin Flush?
A niacin flush is a temporary reddening and warming of the skin, usually on the face, neck, chest, and arms. It’s caused by vasodilation—the widening of blood vessels—triggered by niacin. -
What Causes It?
When you take niacin, it stimulates the release of prostaglandins, which expand capillaries and increase blood flow near the skin’s surface. This causes:
Redness
Warmth or heat
Itching or tingling
Occasionally mild burning
The effect typically begins 15–30 minutes after taking niacin and can last up to an hour.
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When Does It Happen?
More likely with immediate-release niacin (e.g., supplements over 50–100 mg). Less common with slow-release or no-flush forms (like inositol hexanicotinate). The Flush may decrease over time as the body adapts.
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Is It Harmful?
No, it’s usually harmless—just uncomfortable. However, very high doses of niacin (above 2000 mg/day) should only be taken under medical supervision due to potential liver toxicity. -
How to Reduce or Prevent a Niacin Flush?
Take niacin with food
Start with a low dose and increase gradually
Try sustained-release or no-flush formulations
Avoid alcohol or hot beverages when taking niacin
Some people use aspirin (81–325 mg) 30 minutes beforehand (consult a doctor first)
